The Final NIH Policy on the Use of a Single Institutional Review Board for Multi-Site Research is effective for grants submitted after January 25, 2018. The policy applies to NIH-funded multi-site studies where each site will conduct the same protocol involving non-exempt human subject research and requires that a single IRB (sIRB) provide IRB approval for all participating sites.
- The policy applies to domestic awardees and participating domestic sites only; foreign sites participating in NIH-funded, multi-site studies are not expected to follow this policy.
- Exceptions to the policy can be requested, based on law or regulation, or due to some other compelling reason.
If you are participating as a site on an applicable sIRB grant application, but are not the primary grant applicant, you still have responsibilities.