- Indiana University Policy on Dual Use Research of Concern and Pathogens with Enhanced Pandemic Potential
- Unites States Government Policy for Oversight of Dual Use Research of Concern and Pathogens with Enhanced Pandemic Potential
- Principal Investigator Self-Assessment Form
- Templates:
- Risk Assessment Template
- Mitigation Plan
DURC Agents
Category 1 Agents
- Abrin
- Bacillus cereus Biovar anthracis
- Botulinum neurotoxins
- Botulinum neurotoxin producing species of Clostridium
- Conotoxins (Short, paralytic alpha conotoxins containing the following amino acid sequence X1CCX2PACGX3X4X5X6CX7)
- Coxiella burnetii
- Crimean-Congo haemorrhagic fever virus
- Diacetoxyscirpenol
- Eastern Equine Encephalitis virus
- Ebolaviruses (including Bombali, Bundibugyo, Ebola, Reston, Sudan, and Tai Forest viruses)
- Francisella tularensis
- Lassa virus
- Lujo virus
- Marburg virus
- Monkeypox virus, clade I
- Reconstructed replication-competent forms of the 1918 pandemic influenza virus containing any portion of the coding regions of all eight gene segments (Reconstructed 1918 Influenza virus)
- Ricin
- Rickettsia prowazekii
- SARS-associated coronavirus (SARS-CoV)
- SARS-CoV/SARS-CoV-2 chimeric viruses resulting from any deliberate manipulation of SARS-CoV-2 to incorporate nucleic acids coding for SARS-CoV virulence factors
- Saxitoxin
- South American Hemorrhagic Fever viruses:
- Chapare
- Guanarito
- Junín
- Machupo
- Sabia
- Staphylococcal enterotoxins (subtypes A,B,C,D,E)
- T-2 toxin
- Tetrodotoxin
- Tick-borne encephalitis complex (flavi) viruses:
- Far-Eastern subtype
- Siberian subtype
- Kyasanur Forest disease virus
- Omsk hemorrhagic fever virus
- Variola major virus (Smallpox virus)
- Variola minor virus (Alastrim)
- Yersinia pestis
Overlap Select Agents and Toxins
- Bacillus anthracis
- Bacillus anthracis Pasteur strain
- Burkholderia mallei
- Burkholderia pseudomallei
- Hendra virus
- Nipah virus
- Rift Valley fever virus (except #1 MP-12 vaccine strain)
- Venezuelan equine encephalitis virus (except TC83 and V3526 strains)
- African swine fever virus
- Avian influenza virus
- Classical swine fever virus
- Foot-and-mouth disease virus
- Goat pox virus
- Lumpy skin disease virus
- Mycoplasma capricolum
- Mycoplasma mycoides
- Newcastle disease virus
- Peste des petits ruminants virus
- Rinderpest virus
- Sheep pox virus
- Swine vesicular disease virus
- Coniothyrium glycines (formerly Phoma glycinicola and Pyrenochaeta glycines)
- Ralstonia solanacearum
- Rathayibacter toxicus
- Sclerophthora rayssiae
- Synchytrium endobioticum
- Xanthomonas oryzae
https://osp.od.nih.gov/wp-content/uploads/NIH_Guidelines.pdf
Risk Group 4 (RG4) - Bacterial Agents
- None
Risk Group 4 (RG4) - Fungal Agents
- None
Risk Group 4 (RG4) - Parasitic Agents
- None
Risk Group 4 (RG4) - Viral Agents
- Arenaviruses
- Chapare virus
- Guanarito virus
- Junín virus (except the candid #1 vaccine strain listed in Appendix B-II-D Risk Group2 (RG2) – Viruses)
- Lassa virus
- Lujo virus
- Machupo virus
- Sabia
- Bunyaviruses (Nairovirus)
- Crimean-Congo hemorrhagic fever virus
- Filoviruses
- Ebolaviruses, including Bombali, Bundibugyo, Ebola, Reston, Sudan, and Tai Forest viruses
- Marburg viruses, including Marburg and Ravn viruses
- Flaviruses - Group B Arboviruses
- Tick-borne encephalitis virus complex including Absetterov, Alkhurma hemorrhagic fever, Central European encephalitis, Hanzalova, Hypr, Kumlinge, Kyasanur Forest disease, Nanjianyin, Omsk hemorrhagic fever, and Russian spring-summer encephalitis viruses
- Herpesviruses (alpha)
- Herpesvirus simiae (Herpes B or Monkey B virus)
- Paramyxoviruses
- Hendra virus
- Nipah virus
- Hemorrhagic fever viruses as yet undefined
Risk Group 3 (RG3) - Bacterial Agents Including Rickettsia*
- Bartonella
- Brucella including canis
- Burkholderia (Pseudomonas) mallei, B. pseudomallei
- Coxiella burnetii (except the Phase II, Nine Mile strain listed in Appendix B-II-A, Risk Group 2 (RG2) - Bacterial Agents Including Chlamydia)
- Francisella tularensis (except those strains listed in Appendix B-II-A, Risk Group 2 (RG2) – Bacterial Agents Including Chlamydia)
- Orientia tsutsugamushi (was tsutsugamushi)
- Pasteurella multocida type B -"buffalo" and other virulent strains
- Rickettsia akari, R. australis, R. canada, R. conorii, R. prowazekii, R. rickettsii, R. siberica, R. typhi ( mooseri)
- Yersinia pestis (except those strains listed in Appendix B-II-A, Risk Group 2 (RG2) - Bacterial Agents Including Chlamydia)
Risk Group 3 (RG3) - Fungal Agents*
- None
Risk Group 3 (RG3) - Parasitic Agents
- None
Risk Group 3 (RG3) - Viruses and Prions*
- Alphaviruses (Togaviruses) - Group A Arboviruses
- Chikungunya virus (except the vaccine strain 181/25 listed in Appendix B-II-D Risk Group2 (RG2) – Viruses)
- Semliki Forest virus
- Venezuelan equine encephalomyelitis virus (except the vaccine strains TC-83 and V3526, see Appendix B-II-D (RG2) – Viruses)
- Other viruses as listed in the reference source (see Section V-C, Footnotes and References of Sections I through IV)
- Arenaviruses
- Flexal
- Lymphocytic choriomeningitis virus (LCM) (neurotropic strains)
- Bunyaviruses
- Hantaviruses, including Hantaan virus
- Rift Valley fever virus (except #1 MP-12)
- Coronaviruses
- SARS-associated coronavirus (SARS-CoV)
- Middle East respiratory syndrome coronavirus (MERS-CoV)
- Flaviviruses - Group B Arboviruses
- Japanese encephalitis virus (except those strains listed in Appendix B-II-D Risk Group2 (RG2) - Viruses)
- Yellow fever virus (except 17-D)
- Other viruses as listed in the reference source (see Section V-C, Footnotes and References of Sections I through IV)
- Orthomyxoviruses
- Influenza viruses 1918-1919 H1N1 (1918 H1N1), human H2N2 (1957-1968), and highly pathogenic avian influenza H5N1 strains within the Goose/Guangdong/96-like H5 lineage (HPAI H5N1).
- Poxviruses
- Monkeypox virus (Clade I & Clade II containing nucleic acids coding for clade I MPVX virus virulence factors)
- Prions
- Transmissible spongiform encephalopathies (TSE) agents (Creutzfeldt-Jacob disease and kuru agents)(see Section V-C, Footnotes and References of Sections I through IV, for containment instruction)
- Human immunodeficiency virus (HIV) types 1 and 2
- Human T cell lymphotropic virus (HTLV) types 1 and 2
- Simian immunodeficiency virus (SIV)
- Mycobacterium tuberculosis, Mycobacterium bovis
- Clade II of MPVX viruses unless containing nucleic acids coding for clade I MPVX virus virulence factors
- Vesicular stomatitis virus
- Coccidioides immitis and Coccidioides posadasii (sporulating cultures; contaminated soil)
- Sporulating cultures of Histoplasma capsulatum, capsulatum var. Duboisii
- Sporulating cultures of Blastomyces (e.g., B. dermatitidis, B. gilchristii)