Some human subjects research studies may require review by and approval from regulatory offices or committees other than the IRB. Depending on the type of review, IRB approval may be withheld until approval has been obtained.

• IU Simon Cancer Center (IUSCC) Scientific Review Committee (SRC): required for prospective cancer-related research utilizing IUSCC patients or resources; documentation of approval required at time of IRB submission unless an exception has been granted.
• Indiana CTSI Scientific Review Committee (SRC): required for greater than minimal risk studies which require review by the convened biomedical IRB and have not undergone a peer-review process; documentation of approval required at time of IRB submission unless an exception has been granted.
• Radiation Safety Committee: required for research involving radiation/radioactivity in addition to what is used for standard clinical treatment; review conducted concurrently with the IRB process; documentation of approval must be provided prior to final IRB approval.
• VA Research & Development (R&D) Committee: required for VA research; review conducted after IRB approval has been granted.
• Institutional Biosafety Committee (IBC): required for research involving recombinant or synthetic nucleic acid molecules; review conducted concurrently with the IRB process; documentation of approval must be provided prior to final IRB approval.

• External IRBs or ethics committees:
  
  • When an external IRB is providing review, documentation of IRB approval is required at time of Reliance Request submission.
  • If required for transnational research, review may be conducted concurrently with the IRB process but it is strongly recommended that documentation of approval be provided at time of IRB submission. Documentation must be provided prior to IRB approval. The approval must cover the same protocol and consent versions reviewed by the IU IRB, including any IRB provisions.