Researchers at IUPUI propose new model for gene regulation
Work by Indiana University researchers sheds new light on how DNA becomes RNA.
In a new paper titled "Epitranscriptomic code and its alterations in human disease," researchers Raja Shekar Kadumuri and Sarath Chandra Janga of the Department of BioHealth Informatics at the IU School of Informatics and Computing at IUPUI explore the factors that control the proteins that translate DNA to RNA.
In their paper, Kadumuri and Janga surveyed and compiled the literature to date on RNA modifications -- a field increasingly being referred to as epitranscriptomics -- and summarized significant findings.
Additionally, they have proposed a new model for how genes are regulated in a cell.
RNA plays an important role in human health. Since many diseases -- neurological diseases, developmental defects, multiple types of cancer -- are directly due to "incorrect" forms of RNA, treatments targeting the components that modify RNA may offer new ways to fight these diseases.