The National Institutes of Health (NIH) recently released several Guide Notices which are highlighted below:
NIH Guide Notice | Title | Release or Effective Date | Purpose |
Updated Implementation Guidance of NIH Policy on Foreign Subawards for Active Projects
| Released July 18, 2025 | Implementation of the NIH Policy on Foreign Subawards (See NOT-OD-25-104) for applications submitted before May 1, 2025, and projects active on or before May 1, 2025. | |
Revision: NIH Policy and Guidelines on the Inclusion of Women and Minorities as Subjects in Clinical Research
| Effective August 16, 2025 | Revising the NIH Policy and Guidelines on the Inclusion of Women and Minorities as Subjects in Clinical Research to align with Executive Order 14168. | |
Supporting Fairness and Originality in NIH Research Applications | Effective for applications submitted on or after September 25, 2025 | Providing guidance to researchers on the appropriate usage of artificial intelligence (AI) to maintain the fairness and originality of NIH’s research application process. NIH is also instituting a new policy limiting the number of applications that NIH will consider per Principal Investigator per calendar year.
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NIH Announces a New Policy Requirement to Train Senior/Key Personnel on Other Support Disclosure Requirements
| Effective October 1, 2025 | New policy requirement that requires NIH recipients to provide training to all faculty and researchers identified as Senior/Key Personnel on the requirement to disclose all research activities and affiliations (active and pending) in Other Support (see Other Support form).
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Flexibilities for Registration and Results Reporting of Prospective Basic Experimental Studies with Human Participants | Effective for applications submitted on or after September 25, 2025 | Indefinitely extends policy flexibilities regarding registration and results reporting per the NIH Policy on the Dissemination of NIH-Funded Clinical Trial Information (NOT-OD-16-149) for a subset of NIH-funded research whose primary purpose is basic experimental studies with humans (BESH) submitted in response to designated BESH Notices of Funding Opportunity (NOFOs).
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